Probing the interaction between U24 from HHV-6A and Smurf2 WW domains

This thesis describes the study of the interaction of the U24 membrane protein, encoded by Human Herpesvirus type-6A (HHV-6A), with WW domains from Smad ubiquitylation regulatory factor 2 (Smurf2) via its PPxY motif. U24 from HHV-6A is of interest because it acts to block endosomal recycling, as med...

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Bibliographic Details
Main Author: Zhang, Rui
Language:English
Published: University of British Columbia 2015
Online Access:http://hdl.handle.net/2429/53953