Regulation of alpha cell function by gp130 receptor signalling in a rodent model of type 2 diabetes
Dysregulated α cell glucagon secretion contributes to post-meal hyperglycemia in pre-diabetes and to hyperglycemia in type 2 diabetes (T2D). Islets in T2D are characterized by chronic inflammation, and recent human data showed increased IL-6 family cytokine expression in T2D islets in a global gene...
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| Language: | English |
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University of British Columbia
2014
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| Online Access: | http://hdl.handle.net/2429/51699 |