EPI-002 accelerates ligand dissociation from androgen receptor by disrupting N-terminus to C-terminus interaction
Constitutively active splice variants of androgen receptor (AR) lacking the ligand-binding domain (LBD) are linked to the development and progression of castration-resistant prostate cancer (CRPC). Recent studies suggest a constitutively active splice variant, ARv⁵⁶⁷es, is capable of interacting...
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| Language: | English |
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University of British Columbia
2013
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| Online Access: | http://hdl.handle.net/2429/45245 |