Signalling in single cell wound healing

Signalling in single cell wound healing

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A single cell, such as a frog egg, is able to repair injuries by orchestrating a localized signalling response on the plasma membrane. Proteins called Rho GTPases are recruited to, and form patterns around, the wound site. Patterning allows testable hypotheses to be made about the structure of the s...

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Main Author: Liao, Laura
Language:English
Published: University of British Columbia 2013
Online Access:http://hdl.handle.net/2429/44784
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spelling ndltd-UBC-oai-circle.library.ubc.ca-2429-447842018-01-05T17:26:46Z Signalling in single cell wound healing Liao, Laura A single cell, such as a frog egg, is able to repair injuries by orchestrating a localized signalling response on the plasma membrane. Proteins called Rho GTPases are recruited to, and form patterns around, the wound site. Patterning allows testable hypotheses to be made about the structure of the signalling network. Here, we extend a Rho GTPase signalling model from Simon et al. (2013) to test how a family of enzymes, protein kinase C (PKC), plays a role in cell repair signalling. Our models let PKCs affect basal Rho GTPase activation and/or inactivation rates, with increasing spatial detail. Ultimately, the model variants do not account for Rho GTPase patterning in all experiments. We suggest a new round of modelling and experiments to correct these issues. Science, Faculty of Mathematics, Department of Graduate 2013-08-13T17:56:30Z 2013-08-13T17:56:30Z 2013 2013-11 Text Thesis/Dissertation http://hdl.handle.net/2429/44784 eng Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ University of British Columbia
collection NDLTD
language English
sources NDLTD
description A single cell, such as a frog egg, is able to repair injuries by orchestrating a localized signalling response on the plasma membrane. Proteins called Rho GTPases are recruited to, and form patterns around, the wound site. Patterning allows testable hypotheses to be made about the structure of the signalling network. Here, we extend a Rho GTPase signalling model from Simon et al. (2013) to test how a family of enzymes, protein kinase C (PKC), plays a role in cell repair signalling. Our models let PKCs affect basal Rho GTPase activation and/or inactivation rates, with increasing spatial detail. Ultimately, the model variants do not account for Rho GTPase patterning in all experiments. We suggest a new round of modelling and experiments to correct these issues. === Science, Faculty of === Mathematics, Department of === Graduate
author Liao, Laura
spellingShingle Liao, Laura
Signalling in single cell wound healing
author_facet Liao, Laura
author_sort Liao, Laura
title Signalling in single cell wound healing
title_short Signalling in single cell wound healing
title_full Signalling in single cell wound healing
title_fullStr Signalling in single cell wound healing
title_full_unstemmed Signalling in single cell wound healing
title_sort signalling in single cell wound healing
publisher University of British Columbia
publishDate 2013
url http://hdl.handle.net/2429/44784
work_keys_str_mv AT liaolaura signallinginsinglecellwoundhealing
_version_ 1718583905960853504

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