Quaternary salt formation of cinnolines

This study was initially undertaken with a view to preparing quaternary salts of cinnoline simulating the structure of the alkaloid papaverine. This would be possible by the synthesis of two compounds, viz., 6,7-dimethoxycinnoline and 3,4-dimethoxybenzyl-chloride. Some difficulty has been encounter...

Full description

Bibliographic Details
Main Author: Powell, Rees Kenneth
Language:English
Published: University of British Columbia 2012
Online Access:http://hdl.handle.net/2429/41455
Description
Summary:This study was initially undertaken with a view to preparing quaternary salts of cinnoline simulating the structure of the alkaloid papaverine. This would be possible by the synthesis of two compounds, viz., 6,7-dimethoxycinnoline and 3,4-dimethoxybenzyl-chloride. Some difficulty has been encountered in the synthesis of the former and from experimental evidence now at hand the latter can be considered to be unstable. Some new examples of quaternary salts of 4-methycinnoline are reported but in general isolation of salts from 4-methycinnoline and benzyl-halides has been found impractical due to their hygroscopic properties. === Science, Faculty of === Chemistry, Department of === Graduate