The role of SHIP1 in modulating disease severity in the K/BxN serum transfer model of rheumatoid arthritis
SHIP1 (SH2 domain containing inositol-5ʼ-phosphatase) is a negative regulator of the phosphatidylinositol-3 kinase (PI3K) pathway. SHIP1 is expressed in hematopoietic cells, and mediates its effect by hydrolyzing PIP₃, an important second messenger generated by the PI3K pathway. In this way, SHIP...
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| Language: | English |
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University of British Columbia
2011
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| Online Access: | http://hdl.handle.net/2429/36676 |