INOS mediates increased RhoA expression and altered cell signaling in diabetic cardiomyopathy
The RhoA/ROCK pathway is a well established signaling pathway which regulates cellular contractility. Previous studies, from this lab have shown that acute inhibition of ROCK improves heart function in 12 week STZ-diabetic rats. Here we wished to determine, 1) whether the RhoA/ROCK pathway was up...
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| Language: | English |
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University of British Columbia
2011
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| Online Access: | http://hdl.handle.net/2429/32344 |