Role of SAP102 in mutant Huntingtin-mediated regulation of NMDA receptor function in the YAC transgenic mouse model of Huntington Disease
Huntington disease (HD) is a dominantly inherited neurodegenerative disease, which is caused by polyglutamine (polyQ) expansion in the protein huntingtin (htt). Increasing evidence suggests that the N-methyl-D-aspartate (NMDA)-type glutamate receptor plays a role in mediating death of striatal me...
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| Language: | English |
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University of British Columbia
2011
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| Online Access: | http://hdl.handle.net/2429/31685 |