Identification and characterization of chromosome instability mutants in the yeast Saccharomyces cerevisiae and implications to human cancer
Chromosome instability (CIN) is a hallmark of cancers and may contribute to tumorigenesis. Many genes involved in maintaining chromosome stability are conserved in eukaryotes, and some are mutated in cancers. The goal of this thesis is to use Saccharomyces cerevisiae as a model to identify and chara...
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| Language: | English |
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University of British Columbia
2011
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| Online Access: | http://hdl.handle.net/2429/31189 |