Synthesis and reactivity of 14-membered keto lactones
A convergent synthesis using dithiane alkylations to produce a long chain hydroxy acid, and subsequent macrolactonization of the latter, yielded the 14-membered macrolides 47 and 58. [ Formulas omitted ] Alkylation of 47 with methyl iodide gave a diastereomeric produ...
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| Language: | English |
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University of British Columbia
2011
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| Online Access: | http://hdl.handle.net/2429/31129 |