Novel peptide-derived cathepsin K inhibitors from Streptomyces

Human cathepsin K is a cysteine protease that is a member of the papain superfamily. It is selectively expressed in osteoclasts where it is involved in collagen type I degradation during bone resorption. As such, cathepsin K represents a potential drug target for the treatment of metabolic bone dise...

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Bibliographic Details
Main Author: Kruglyak, Natalya
Language:English
Published: University of British Columbia 2010
Online Access:http://hdl.handle.net/2429/30305