ILK represses E-cadherin expression by regulating PARP-1 binding to the Snail promoter
The loss of E-cadherin, a critical component of the adherence junctions, is implicated in the metastasis of carcinomas and correlates with tumour grade. Here we show that in PC3 cells loss of Integrin-Linked Kinase (ILK), AKT/PKB or Snail-1, results in the re-expression of E-cadherin at both the mRN...
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| Language: | English |
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University of British Columbia
2010
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| Online Access: | http://hdl.handle.net/2429/29781 |