The in vitro characterization of the drug-protein binding of racemic propafenone, and its active metabolite 5-hydroxypropafenone in human serum, and in solutions of isolated human serum proteins
An accurate plasma concentration-response relationship for propafenone (PF), a potent class 1 antiarrhythmic agent, has not yet been defined. A general pharmacological premise suggests that only the free drug is available to contribute to the observed pharmacological response. It has previously been...
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| Language: | English |
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University of British Columbia
2010
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| Online Access: | http://hdl.handle.net/2429/29048 |