Synthesis of [beta]-keto lactones and the synthetic consequences of the conformational preferences of 14-membered lactones
The preparation of the β-keto lactones 1̲9̲ via intramolecular alcoholysis of hydroxy Meldrum's acid derivatives was examined. Good yields of the 6- and 14-membered compounds were obtained, but the method was completely unsuccessful for medium-size rings. An investigation was conducted on the...
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| Language: | English |
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University of British Columbia
2010
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| Online Access: | http://hdl.handle.net/2429/25954 |