Mitochondrial potassium sequestration and neuroprotection is mediated by connexin43
Reduction in the expression of the astrocyte gap junction protein connexin43 (Cx43) increases infarct volume following middle cerebral artery occlusion (MCAO). A potential mechanism for this effect is disruption of ion buffering. During ischemia, extracellular potassium concentration ([K⁺]₀) rises...
| Main Author: | |
|---|---|
| Language: | English |
| Published: |
University of British Columbia
2010
|
| Online Access: | http://hdl.handle.net/2429/24885 |