Membrane localization of RasGRPs by C1 domains
Ras and Rap GTPases are membrane-bound activators of signal transduction pathways that regulate several cell processes including proliferation, apoptosis and adhesion. Guanine nucleotide exchange factors (GEF5) positively regulate Ras and Rap GTPases by exchanging guanosine diphosphate (GDP) for gua...
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| Language: | English |
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University of British Columbia
2010
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| Online Access: | http://hdl.handle.net/2429/24211 |