Mechanistic studies and manipulation of the enzymes in sialic acid and pseudaminic acid biosynthesis

The Neisseria meningitidis sialic acid synthase (NeuB) catalyzes the metal-dependent condensation of N-acetylmannosamine (ManNAc) and phosphoenolpyruvate (PEP) to generate N-acetylneuraminic acid. This work describes the synthesis and characterization of the first potent inhibitor of sialic acid syn...

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Bibliographic Details
Main Author: Liu, Feng
Language:English
Published: University of British Columbia 2010
Online Access:http://hdl.handle.net/2429/24013

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