Hollow fibre bioreactor delayed start-up, pH gradients and CHO cell product harvesting
Hollow fibre bioreactors (HFBRs) are widely used for monoclonal antibody production. Compared to spinners inoculated in parallel, ultrafiltration HFBR start-up lags are often significantly longer and HFBRs have a higher frequency of failure. A number of potential causes of these problems were ide...
| Main Author: | |
|---|---|
| Language: | English |
| Published: |
2009
|
| Online Access: | http://hdl.handle.net/2429/17197 |