The role of SRC family protein tyrosine kinases and the GAB1 adapter protein in BCR-mediated activation of AKT
Antibody production by B lymphocytes is important for the eradication of foreign pathogens and requires signaling by the BCR. Crosslinking of the BCR results in the activation of three main signaling pathways — the PI 3-kinase, MAP kinase and PLC-γ2 pathways. It is proposed that various combinations...
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| Language: | English |
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2009
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| Online Access: | http://hdl.handle.net/2429/16997 |