| Summary: | Vessel size imaging is a relatively new technique in Magnetic Resonance
Imaging. By measuring the change in the transverse relaxation constants R₂ and R*₂ caused by the injection of a superparamagnetic contrast agent
known as ferumoxtran, it is possible to create a map of vessel size index,
which is a weighted average of the vessel radius. This technique was used
on the Shionogi tumour model to monitor changes in vasculature as a result
of androgen ablation by way of castration. A vessel size index map
was created for androgen dependent, regressing and androgen independent
tumours, and a statistically significant difference between the stages was
found. Regressing tumours had the smallest vessel size index followed by
androgen dependent and then androgen independent tumours. In addition,
a qualitative comparison with Hoechst stained tumours was made. === Science, Faculty of === Physics and Astronomy, Department of === Graduate
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