Heterogeneity of the folding mechanism : testing the predictions of free energy functional theory
The free energy functional theory of protein folding presents a framework to explain the effects of heterogeneity in the folding mechanism. These heterogeneity effects introduce changes in the folding free energy barriers that govern the rates for 2-state folding proteins. Here in this thesis, we...
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2009
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ndltd-UBC-oai-circle.library.ubc.ca-2429-156382018-01-05T17:37:54Z Heterogeneity of the folding mechanism : testing the predictions of free energy functional theory Oztop, Baris The free energy functional theory of protein folding presents a framework to explain the effects of heterogeneity in the folding mechanism. These heterogeneity effects introduce changes in the folding free energy barriers that govern the rates for 2-state folding proteins. Here in this thesis, we focused on checking the validity of the predictions of free energy functional theory by using the data from simulations of Cα , Gō proteins and from experiments. Our results show that folding rates correlate with the degree of heterogeneity in the formation of native contacts for both simulated structures and real proteins. Science, Faculty of Physics and Astronomy, Department of Graduate 2009-11-24T21:04:27Z 2009-11-24T21:04:27Z 2004 2004-05 Text Thesis/Dissertation http://hdl.handle.net/2429/15638 eng For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use. 2228173 bytes application/pdf |
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NDLTD |
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English |
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Others
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NDLTD |
| description |
The free energy functional theory of protein folding presents a framework to
explain the effects of heterogeneity in the folding mechanism. These heterogeneity
effects introduce changes in the folding free energy barriers that govern
the rates for 2-state folding proteins. Here in this thesis, we focused on checking
the validity of the predictions of free energy functional theory by using the data
from simulations of Cα , Gō proteins and from experiments. Our results show
that folding rates correlate with the degree of heterogeneity in the formation of
native contacts for both simulated structures and real proteins. === Science, Faculty of === Physics and Astronomy, Department of === Graduate |
| author |
Oztop, Baris |
| spellingShingle |
Oztop, Baris Heterogeneity of the folding mechanism : testing the predictions of free energy functional theory |
| author_facet |
Oztop, Baris |
| author_sort |
Oztop, Baris |
| title |
Heterogeneity of the folding mechanism : testing the predictions of free energy functional theory |
| title_short |
Heterogeneity of the folding mechanism : testing the predictions of free energy functional theory |
| title_full |
Heterogeneity of the folding mechanism : testing the predictions of free energy functional theory |
| title_fullStr |
Heterogeneity of the folding mechanism : testing the predictions of free energy functional theory |
| title_full_unstemmed |
Heterogeneity of the folding mechanism : testing the predictions of free energy functional theory |
| title_sort |
heterogeneity of the folding mechanism : testing the predictions of free energy functional theory |
| publishDate |
2009 |
| url |
http://hdl.handle.net/2429/15638 |
| work_keys_str_mv |
AT oztopbaris heterogeneityofthefoldingmechanismtestingthepredictionsoffreeenergyfunctionaltheory |
| _version_ |
1718589970923388928 |