Heterogeneity of the folding mechanism : testing the predictions of free energy functional theory
The free energy functional theory of protein folding presents a framework to explain the effects of heterogeneity in the folding mechanism. These heterogeneity effects introduce changes in the folding free energy barriers that govern the rates for 2-state folding proteins. Here in this thesis, we...
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| Format: | Others |
| Language: | English |
| Published: |
2009
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| Online Access: | http://hdl.handle.net/2429/15638 |
| Summary: | The free energy functional theory of protein folding presents a framework to
explain the effects of heterogeneity in the folding mechanism. These heterogeneity
effects introduce changes in the folding free energy barriers that govern
the rates for 2-state folding proteins. Here in this thesis, we focused on checking
the validity of the predictions of free energy functional theory by using the data
from simulations of Cα , Gō proteins and from experiments. Our results show
that folding rates correlate with the degree of heterogeneity in the formation of
native contacts for both simulated structures and real proteins. === Science, Faculty of === Physics and Astronomy, Department of === Graduate |
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