Effects of Twelve-weeks Endurance Training on Endothelial Function in Aging Hypertension

• Main Authors: Liu, Jia-Liang, 劉家良
• Other Authors: Yang, Ai-Lun
• Format: Others
• Language: zh-TW
• Published: 2019
• Online Access: http://ndltd.ncl.edu.tw/handle/5tbs2d

碩士 === 臺北市立大學 === 運動科學研究所 === 107 === Background and purpose : Previous studies have demonstrated that the risk of cardiovascular disease would be increased with advanced aging. Aging causes the decreases of cardiovascular function, including arterial hypertension, vascular stiffness, and endothelial dysfunction. Endurance exercise is well known in improving cardiovascular health and lowering the risk of cardiovascular disease. However, the influences of endurance exercise on aging hypertension-related cardiovascular function have not been clarified. Therefore, this study aimed to investigate the effects of long-term endurance training on endothelial function in aging hypertension, and underlying mechanisms. Methods : Male aging spontaneously hypertensive rats (SHR) were randomly divided into exercise group (48wk-SHR-EX, n = 8) and control (48wk-SHR, n = 8) group. The age-matched Wistar-Kyoto (48wk-WKY, n = 8) rats were used as the normotensive control group. The exercise group received the endurance training for 12 weeks, otherwise, the other groups did not receive exercise intervention. Finally, the endothelial function, serum nitric oxide (NO), oxidative and antioxidant indicators were measured, including superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA). The results were compared among three groups statistically. Results : Our results showed that the endothelium-dependent vasodilation in the 48wk-SHR-EX group was significantly higher than the 48wk-SHR group (p < 0.05), but this vasodilation was significantly lower than the 48wk-WKY group (p < 0.05). The endothelium-independent vasodilation in the 48wk-SHR-EX group was significantly higher than the 48wk-SHR group (p < 0.05). In addition, the serum NO concentration in the 48wk-SHR-EX group was significantly higher than the 48wk-SHR group (p < 0.05). The antioxidant activities (SOD and CAT) in the 48wk-SHR-EX group were significantly higher than the 48wk-SHR group (p < 0.05). However, the MDA concentration in the 48wk-SHR-EX group was significantly lower than the 48wk-SHR group (p < 0.05). Conclusion : This study suggested that long-term endurance training effectively ameliorated endothelial function in aging hypertensive rats, and enhanced the NO concentration and antioxidant indicators.