| Summary: | 碩士 === 臺北市立大學 === 運動科學研究所 === 107 === Purpose: To investigate the effect of systemic hypoxia-reoxygenation or -hyperoxia preconditioning on aerobic exercise performance and acute heavy resistance exercise-induced muscle damage in athletes. Methods: In study I, 11 male athletes are recruited in single-blind, randomized- controlled crossover rotated trial, supplied either control (CON) (21% O2) or hypoxia- hyperoxia (10- 99% O2) (HH) (5 min hypoxia- 5 min hyperoxia a circle for 6 circles). After 30 min, an acute heavy resistance exercise (AHRET) was performed. Heart rates variability (HRV), muscle hemodynamic, inflammation, oxidative stress and muscle strength are determined before intervention, immediately, 24 and 48 hours after exercise. In study II, 9 male athletes are supplied normoxia or three modes of hypoxia-reoxygenation or -hyperoxia (10-21, 60 or 99% O2) (HR, HHI, HH). Hemodynamic changes of muscle and brain are measured during intervention, following by a maximal aerobic capacity (VO2max) test 30 minutes after intervention. Result: In study I, there are significantly lower creatine kinase and myoglobin in HH than that in CON 24 (p<0.05; p<0.05) and 48 hours (p=0.08; p=0.05) after AHRET. There is significantly higher IL-6 (p<0.05) in HH than that in CON 24 and 48 hours after AHRET. No significant difference in other markers between two groups. In study II, there are significantly higher VO2max (p<0.05) and exercise time (p<0.05) in HH group. Conclusion: Systemic hypoxia-hyperoxia preconditioning could reduce exercise-induced muscle damage and enhance aerobic exercise performance. These effects may be associated with the increase of inflammatory marker and the decrease in body anabolism.
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