| Summary: | 碩士 === 大同大學 === 材料工程學系(所) === 107 === Development of biocompatible and multifunctional nanovehicle has recently attracted much attention for cancer theranostics. In this study, super paramagnetic iron oxide nanoparticle (SPION) nanorod clusters coated with europium doping calcium-deficient hydroxyapatite- polyethylenimine (Eu:de-HAP-PEI) are synthesized through co-precipitation process to form core/shell nanostructure. The luminescent SPION@Eu:de-HAP-PEI nanorods are explored for the loading and controlled delivery of drugs. The photoluminescence (PL) intensity of SPION@Eu:de-HAP-PEI nanorods can be adjusted by varying Eu3+ concentrations. The magnetic property of SPION@Eu:de-HAP-PEI nanorods increase with the increase of SPION weight ratio. More importantly, the SPION@Eu:de-HAP-PEI nanorods show high drug encapsulation capacity and sustained drug release profile, which is governed by diffusion phenomenon. The SPION@Eu:de-HAP-PEI nanorods exhibit magnetic-targeted characteristic, high drug loading content, high toxicity to tumor cells, low side effects to normal cells, and PL imaging functions. These findings prove that the SPION@Eu:de-HAP-PEI nanorods have great potential as novel tumor-targeting theranostic agents for simultaneous PL imaging and efficient anti-tumor treatment.
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