Phospho-Lipid Surface Modification of Upconversion Nanoparticles for Biological Application

• Main Authors: Kuan-Yu Chen, 陳冠宇
• Other Authors: Yu-Hsu Chang
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/72dkpq

碩士 === 國立臺北科技大學 === 資源工程研究所 === 107 === The low energy, non-phototoxic, and deep tissue penetrative features of near infrared (NIR) light makes it a better biocompatible light source than direct UV irradiation for photolysis (bioeffectors photo-release) reactions when combined with upconversion nanoparticles (UCNPs). UCNPs can absorb NIR light and generate antiStoke-shifted (blue-shifted) emission including UV light. With NIR laser excitable and UV emissive properties of UCNP, it allows photolysis reaction (near the surface of UCNP) to be triggered upon NIR light irradiation. Using UCNP as a photo-release platform, the phototoxicity is lowered since excitation light source is replaced from UV to NIR. In this study, we screened several phospho-lipid formulations to surface-coating UCNP to study the colloidally stability and upconverting emission property in physiological solution. A photoresponsive peptide was tested for conjugation and photoactivation.