Study on Polymeric Microsphere on Polydimethylsiloxan with Drug Carrier Membrane Based on Atmospheric Plasma Technique.

• Main Authors: KE-CHI FU, 傅可棨
• Other Authors: Yu-Lin Kuo
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/xh9k24

碩士 === 國立臺灣科技大學 === 機械工程系 === 107 === Polydimethylsiloxane (PDMS) is the most widely and one of the most versatile material used in the construction of biotechnology. However, the surface of PDMS is naturally hydrophobic limited its use. Atmospheric pressure plasma jet (APPJ) technology has been widely used for modify surface of PDMS. Conversely, the quick hydrophobic recovery is one of the main issues limiting the use of plasma technology. To overcome the problem of hydrophilic aging. HEMA microspheres solution were simultaneously grafted onto PDMS using a two-step plasma treatment (TSPT). The first step of this method: plasma pretreatment of the PDMS, spin-coating HEMA microspheres mixtures solution, and drying. The second step was carried out by plasma polymerization of preabsorbed reactive HEMA monomers on the surface of dried pretreated films. The PDMS sample were treated at different plasma power (100W/150W/200W) with 1% O2/Ar, while the wettability and ageing effects were study by water contact angle and DPPH radical test. Surface chemical compound were measured by ATR-FTIR which can prove the grafting film had been grafted onto PDMS. It was also observed the biocompatibility by cultured Fibroblast cells (L929), anti protein absorption character by absorbing Bovine serum albumin (BSA), drug delivering property by linear drug releasing and antibacterial character. Keywords: APPJ, TSPT method, Hydrophilic aging, HEMA micro-carrier, Drug releasing