| Summary: | 碩士 === 國立臺灣大學 === 醫學工程學研究所 === 107 === The purpose of this study was to develop a three-dimensional(3-D) positioning system for MR-compatible focused ultrasound transducers with magnetic imaging guided for brain tumor therapy. Using Magnetic Resonance Imaging (MRI) combined with focused ultrasound for brain thermal therapy, and hence it can be used for precise guidance and treatment simultaneously. It is a non-invasive therapy, and can be combined with temperature imaging and nanodrugs to improve its diagnosis and treatment.
In this study, polyoxymethylene (POM) material was used to make the positioning platform, which was moved by a screw nut in a manual rotation mode. The positioning platform has three degrees of freedom , and one rotation, and the movement rang of X,Y and Z is 50 mm, and the maximum angle of rotation is 30 degrees. When using a spherical array of ultrasonic transducers,the ultrasonic transducer is filled with degassed water and installed in the 3-D positioning platform ; The positioning platform is made of MR compatible materials, including POM, PLA, copper alloy, aluminum alloy, acrylic, etc., and with an MR compatible scale tape feedback . NHRI 3T MRI system was used and it was a challenge to design and manufacture MR-compatible 3-D positioning platforms with non-magnetic materials and limited space constraints.
The MRI compatibility optical scale is tested for the accuracy of the movement function of the 3-D positioning platform with the spherical array transducer, and the error is less than 250 μm after correction. The results of MRI imaging test, showed that it has sufficient MR compatibility and it would not interfere with the MR image. The platform could accurately perform the positioning work for the spherical array ultrasonic transducer.
In this study, a 3-D platform for brain tumor ultrasound thermal therapy was developed with the MRI system. This platform has considerable positioning accuracy and MR compatibility, and should be able to effectively carry a spherical array ultrasonic transducer for brain tumor thermal therapy.
|
|---|
