Effects of Magnesium supplementation on cerebral hemodynamic parameters and cognitive function

• Main Authors: Sew-Li Chew, 周秀莉
• Other Authors: Wen-Harn Pan
• Format: Others
• Language: zh-TW
• Published: 2019
• Online Access: http://ndltd.ncl.edu.tw/handle/2ccw6b

碩士 === 國立臺灣大學 === 生化科技學系 === 107 === This study intended to evaluate the short-term effect of magnesium supplement at a Daily Recommended Index (DRI) level on cognitive function and on certain hemodynamic parameters. This study aimed to recruit cognitively impaired participants aged 60 and over who determined cognitive scores ≤ 26 using Mini-Mental State Examination (MMSE). Using a double-blind randomized placebo-controlled intervention trial design, participants were divided into magnesium intervention group and placebo group. Both groups were evaluated by Montreal Cognitive Assessment (MoCA), working memory test, carotid artery flow velocity, urinary magnesium and food frequency questionnaire. We recruited 50 (21 men and 29 women) ≥60 years elderly (placebo group: 75.0± 7.4 years; intervention group: 75.3± 7.6 years) with MMSE and MoCA cognitive score ≤26. In body mass index(BMI), education level, medical history(Hypertension, Heart disease, Type 2 Diabetes Mellitus and Hyperlipidemia) and daily magnesium intake, there were not significant difference between both groups. At baseline, urinary magnesium (placebo group: 5.4 ± 2.4 mg/dL, intervention group: 6.5 ± 5.2 mg/dL), urinary creatinine (placebo group: 70.7 ± 40.2 mg/dL, intervention group: 88.7 ± 52.8 mg/dL) and urinary magnesium/creatinine (placebo group: 0.088 ± 0.032, intervention group: 0.076 ± 0.036) did not significant difference between groups. The score of MoCA in placebo group was higher than intervention group but the difference was not significant (placebo group: 20.6 ±4.0, intervention group: 18.0 ± 6.2, P-value=0.0896) in baseline. Post-test was conducted two hours after intervention group was consumed 300mg magnesium citrate. Results indicated that there were no significant differences for all post-test measures between groups after two-hour intervention except for their MoCA score (placebo group: 23.8 ± 4.0，intervention group: 20.1 ± 6.6 , P-value=0.0226) and mean velocity of common carotid artery in left (placebo group: -1.57 ± 6.40 cm/s, intervention group: -5.11 ± 5.35 cm/s，P-value=0.0381). The amounts of urinary magnesium (placebo group: 4.5 ± 2.3 mg/dL, intervention group: 6.6 ± 4.4 mg/dL) and creatinine (placebo group: 57.5 ±34.5 mg/dL, intervention group: 87.8 ±63.0 mg/dL) were found higher in the intervention group compared to placebo group, but the differences were not statistically significant. Two hours after consuming magnesium citrate, urinary magnesium/creatinine increases were observed in both groups(placebo group: 0.090 ±0.038, intervention group: 0.085 ± 0.035) even though the changes were not significant. The one-time intervention of magnesium could not improve blood flow of carotid and cognitive function in 3 hours in this study. Our finding suggested that long-term magnesium intervention has more health-improving effect. Key words：Magnesium, double-blind, elderly, cognitive function, one-time intervention