| Summary: | 碩士 === 國立臺灣大學 === 化學工程學研究所 === 107 === Coating technology has been widely applied to semi-conductor industry and biomedical implants and has provided long-term stability and further modification for several decades. However, the surface modification was not dynamic enough to satisfy the external stimuli response and sophisticated biological system. Herein, in this study, an erasable coating was synthesized to perform surface modification of rendering a precise and yet flexible interface property and was able to provide defined and confined surface chemistry/function, and moreover, was able to erase such installed chemistry/function in a time scale or location of interests; or in addition, with the accessibility to reconnect the interface to a new chemistry/function. The coating was composed of a backbone structure of poly-para-xylylene and a side chain functionality of disulfanyl propanoic acid, and the coating was prepared via a vapor-phased polymerization/deposition process featuring a well-known advantage of being conformal to the coated substrates and was able to apply the coating with regardless of the substrate materials. The functionality of disulfanyl propanoic acid of the coating provides rationale capability to (i) access specific conjugation through the carboxyl group, (ii) erase the already-installed chemistry/function from (i) via the integrated disulfide load-lock moiety and in a controlled and confined manner, and (iii) reactivate the surface property to a second divergent chemistry/function via the additional feature of using the disulfide interchange reaction. The important and unique capability of erasable coating to control interface properties was showed by fluorescent immobilization. In addition, based on using the coating technology, the modification of a surface was demonstrated with the creation of a hybrid presentation and a geographically-defined hydrophilic/hydrophobic wetting property on the same surface, as well as a programmed control of alternating the wetting property between the hydrophilic and hydrophobic state in two complete cycles was shown.
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