The Resonance Properties and Biosensing Application of Metal- Dielectric-Metal Coated Periodic Nanowire

碩士 === 國立臺灣海洋大學 === 光電科學研究所 === 107 === This paper describes the use of metal-dielectric-metal processes to make bio-sensing chips. Base on the theory of surface plasmon resonance. Making a metal- dielectric-metal film structure on a periodic injection molding substrate, an accurate design of transm...

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Main Authors: Wang, Yu-Kai, 王昱凱
Other Authors: Wei, Pei-Kuen
Format: Others
Language:zh-TW
Published: 2019
Online Access:http://ndltd.ncl.edu.tw/handle/uv3thd
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spelling ndltd-TW-107NTOU56140022019-05-16T01:44:46Z http://ndltd.ncl.edu.tw/handle/uv3thd The Resonance Properties and Biosensing Application of Metal- Dielectric-Metal Coated Periodic Nanowire 週期性奈米線披覆金屬-介質-金屬結構之共振特性探討及生醫感測應用 Wang, Yu-Kai 王昱凱 碩士 國立臺灣海洋大學 光電科學研究所 107 This paper describes the use of metal-dielectric-metal processes to make bio-sensing chips. Base on the theory of surface plasmon resonance. Making a metal- dielectric-metal film structure on a periodic injection molding substrate, an accurate design of transmission and reflection spectra, reproducibility, high throughput, high sensitivity, and instant detection. In this experiment, different thicknesses of metal layer are coated using thermal evaporation, and metal thickness is measured using a film thickness profiler (α-step) to adjust the metal and dielectric film thickness parameters. Followed by a transmissive optical system, the periodic injection molding is measured to detect changes in wavelength and intensity of the microchip. The wavelength of the metal- dielectric -metal thin film structure is designed to be coupled with the surface plasmon resonance wavelength. Using the microfluidic channel system to carry out refractive index test with different environmental concentrations of glycerol water, it is found that when the incident light source illuminates the sample, there will be a certain angle to increase the wavelength sensitivity and the wavelength shift to the blue shift (short wavelength). In order to confirm and explain the blue shift phenomenon, where negative refraction is used to explain the problem and to make samples of repetition for analysis. In the part of the biological experiment, the surface was modified with cysteamine and glutaraldehyde solution, and the rate of coating was improved without removing the conditions in the modification step. Subsequently, the microfluidic channel system was sealed on the chip, and bovine serum albumin (BSA) and immunoglobulin (IgG) biological solution was used. Both were separately formulated with different concentrations for analytical measurement. On the metal-dielectric-metal detection chip, the biochip for detection application can be enhanced, and its very research and development for the detection biosensing chip which result the blue shift phenomenon of the wavelength band in the future. Keywords: Surface Plasmon Resonance (SPR), Nanostructure, Multilayer Structure, Non-labeled, High Throughput, Biosensing, Injection Molding Microchip. Wei, Pei-Kuen Chiang, Hai-Pang 魏培坤 江海邦 2019 學位論文 ; thesis 62 zh-TW
collection NDLTD
language zh-TW
format Others
sources NDLTD
description 碩士 === 國立臺灣海洋大學 === 光電科學研究所 === 107 === This paper describes the use of metal-dielectric-metal processes to make bio-sensing chips. Base on the theory of surface plasmon resonance. Making a metal- dielectric-metal film structure on a periodic injection molding substrate, an accurate design of transmission and reflection spectra, reproducibility, high throughput, high sensitivity, and instant detection. In this experiment, different thicknesses of metal layer are coated using thermal evaporation, and metal thickness is measured using a film thickness profiler (α-step) to adjust the metal and dielectric film thickness parameters. Followed by a transmissive optical system, the periodic injection molding is measured to detect changes in wavelength and intensity of the microchip. The wavelength of the metal- dielectric -metal thin film structure is designed to be coupled with the surface plasmon resonance wavelength. Using the microfluidic channel system to carry out refractive index test with different environmental concentrations of glycerol water, it is found that when the incident light source illuminates the sample, there will be a certain angle to increase the wavelength sensitivity and the wavelength shift to the blue shift (short wavelength). In order to confirm and explain the blue shift phenomenon, where negative refraction is used to explain the problem and to make samples of repetition for analysis. In the part of the biological experiment, the surface was modified with cysteamine and glutaraldehyde solution, and the rate of coating was improved without removing the conditions in the modification step. Subsequently, the microfluidic channel system was sealed on the chip, and bovine serum albumin (BSA) and immunoglobulin (IgG) biological solution was used. Both were separately formulated with different concentrations for analytical measurement. On the metal-dielectric-metal detection chip, the biochip for detection application can be enhanced, and its very research and development for the detection biosensing chip which result the blue shift phenomenon of the wavelength band in the future. Keywords: Surface Plasmon Resonance (SPR), Nanostructure, Multilayer Structure, Non-labeled, High Throughput, Biosensing, Injection Molding Microchip.
author2 Wei, Pei-Kuen
author_facet Wei, Pei-Kuen
Wang, Yu-Kai
王昱凱
author Wang, Yu-Kai
王昱凱
spellingShingle Wang, Yu-Kai
王昱凱
The Resonance Properties and Biosensing Application of Metal- Dielectric-Metal Coated Periodic Nanowire
author_sort Wang, Yu-Kai
title The Resonance Properties and Biosensing Application of Metal- Dielectric-Metal Coated Periodic Nanowire
title_short The Resonance Properties and Biosensing Application of Metal- Dielectric-Metal Coated Periodic Nanowire
title_full The Resonance Properties and Biosensing Application of Metal- Dielectric-Metal Coated Periodic Nanowire
title_fullStr The Resonance Properties and Biosensing Application of Metal- Dielectric-Metal Coated Periodic Nanowire
title_full_unstemmed The Resonance Properties and Biosensing Application of Metal- Dielectric-Metal Coated Periodic Nanowire
title_sort resonance properties and biosensing application of metal- dielectric-metal coated periodic nanowire
publishDate 2019
url http://ndltd.ncl.edu.tw/handle/uv3thd
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