The relationship of body mass index and symptom clusters with postoperative recurrence in thyroid cancer

• Main Authors: WU,YU-YING, 吳寓萾
• Other Authors: Chiou, Piao-Yi
• Format: Others
• Language: zh-TW
• Published: 2019
• Online Access: http://ndltd.ncl.edu.tw/handle/t4765m

碩士 === 國立臺北護理健康大學 === 護理研究所 === 107 === The prognostic schemes of thyroid cancer are mainly based on data from Western countries. However, considering the racial differences, it would be of interest to analyze the impact of prognostic factors in the context of Asian settings. This study utilized comparative descriptive designs to retrospectively review the thyroid cancer database and related medical records from January 1, 2001, to December 31, 2017. Controlling for age, sex, and disease stage, a total of 57 patients who had postoperative recurrence were matched to 114 patients who had no recurrence during follow-up. Overall, 171 patients were included in the analysis to investigate factors for postoperative recurrence in thyroid cancer. Using the Cox proportional hazards model, multivariate analysis revealed that the presence of family history of thyroid cancer (hazards ratio [HR] = 2.463, 95% confidence interval [CI] = 1.115 to 5.441, p = 0.026), obesity defined as body mass index > 27 kg/m2 (HR = 1.981, 95% CI = 1.040 to 3.773, p = 0.038), and the number of symptom clusters > 3 (HR = 4.184, 95% CI = 2.419 to 7.234, p = < 0.001) were independent risk factors related to postoperative recurrence. In conclusion, a positive family history, obesity, and higher symptom burden might be associated with recurrence after surgical treatment of differentiated thyroid cancer. Patients who exhibit these factors may need heightened surveillance.