| Summary: | 博士 === 國立中山大學 === 機械與機電工程學系研究所 === 107 === Biomedical materials should be biodegradable (enzymatic degradation and hydrolysis) because biodegradable materials in clinical applications show excellent biocompatibility. Among them, polycaprolactone and sodium alginate are degradable, biocompatible and bioabsorbable. The blood vessel size of each person''s liver is different. The physician determines the size of the blood vessel and proposes the size of the embolization microcarriers. The particle size range of the microcarriers produced by the traditional emulsification method is too wide, and the required microcarriers were screened, and the remaining materials were wasted. Therefore, this research develops a microcarrier production system for ultrasonic-assisted biomedical materials, which enables microcarriers to have functional and uniform microcarrier technology. This thesis develops the ultrasonic module atomization mechanism, and the atomization droplets control the particle size. By applying high-frequency mechanical vibration generated by piezoelectric kinetic energy, when standing waves occur in the nozzle, the vibration energy is sufficient to overcome the surface tension of the solution to obtain fine droplets. It must be sufficient to overcome the surface tension of the solution to obtain fine droplets, and the emulsification process can be used to prepare a particle size uniformity controllable microcarrier. In this study, the ultrasonic carrier system was used to assist the biomedical materials to make microcarriers. The liquid supply rate was measured at 60 ml/h, and the droplets had high uniformity after atomization. The uniformity of the particle size range of 20-80 μm was 68-72. %, with the universal polycaprolactone and natural material sodium alginate, find the best production conditions and impact factors by a uniform experimental method and Taguchi design experiment method. The results showed that the best parameters of polycaprolactone were: polycaprolactone solution flow rate 1.4 ml/min, polyvinyl alcohol concentration 13.3 wt%, the most uniform microcarriers, the particle size range of 45 ± 10 μm, uniformity About 67%, due to the subsequent addition of natural material sodium alginate, the polycaprolactone uniform method was optimized to bring into the Taguchi method, and the optimal combination condition of sodium alginate microcarrier was determined as the solution ratio of 0.1, calcium chloride solution. 6 wt%, sodium alginate 2.5 wt%, collection distance 8 cm, syringe flow 30 ml/h, stirring speed 150 rpm, injection needle diameter 0.25 mm, curing time 2 h, identified by influential analysis Factor, the influence size is the collection distance > the concentration of calcium chloride solution > cure time > stirring speed > injection needle diameter. Finally, the best drug of polycaprolactone is mixed with the cancer drug doxorubicin to prepare drug-loaded microcarriers. The microcarriers have a particle size of 1 to 30 μm, a drug loading efficiency of about 42%, and a microcarrier coating effect of 3.5%.
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