Changes of cerebral cortical thickness in migraine

• Main Authors: Bai-Shiang Lu, 呂百翔
• Other Authors: Tzu-Chao Chuang
• Format: Others
• Language: zh-TW
• Published: 2019
• Online Access: http://ndltd.ncl.edu.tw/handle/43p7s6

碩士 === 國立中山大學 === 電機工程學系研究所 === 107 === Migraine is associated with a variety of symptoms and its pathogenic mechanism is complex. Many imaging studies have observed the changes of brain function in migraineurs. However, it is still not clear whether anatomical abnormalities occur. The purpose of this study is to investigate the structural change of cerebral cortex of migraine by measuring cortical thickness. In this study, high resolution three-dimensional T1 weighted magnetic resonance imaging were corrected at 3.0 Tesla on 12 migraine patients without aura and 12 healthy subjects. Cortical thickness measurement is performed by FreeSurfer, an automatic software well-known in research society of neuroscience. For group comparison, the general linear model is used to remove the effect of age and gender on cortical thickness. Results showed that compared with the control group, increased thickness was found at left postcentral gyrus, right rostral middle frontal gyrus, bilateral inferior parietal lobule, right insula and right posterior cingulate cortex on patients with migraine. In addition, cortical thickness of migraineurs decreases at left precentral gyrus, left lateral orbitofrontal gyrus and left isthmus cingulate. Among these regions, some are involved in afferent drive and regulation of pain. However, only three clusters, including left lateral orbitofrontal gyrus, left inferior parietal lobule and right insula, remain after clusterwise correction for multiple comparison, and none with a cluster-wise p value less than 0.05, indicating no significant difference. Results of this study are partly consistent with that in previous literatures, but not reach complete agreement with any of it. In fact, no specific change in cortical thickness can be repeatedly observed apparent among previous studies, in which none is totally consistent with each other. All imply that neither unanimous nor apparent change of cerebral cortical thickness in migraine has been found so far. As a result, to further investigate the structureal abnormalities related to headache in the future, recruitment of more subjects and experiment design with consideration of more factors, such as medication history and frequency of occurrence, should be strongly suggested.