| Summary: | 碩士 === 國防醫學院 === 公共衛生學研究所 === 107 === Background: Taiwan is known to fully implement neonatal hepatitis B vaccination, which is a major achievement in the history of Taiwan's public health. Because this policy has greatly reduced liver disease caused by hepatitis B virus, but hepatitis C virus has not been developed. To a very effective vaccine, although new antiviral drugs have been heard in recent years, so far, hepatitis C virus cannot be prevented by vaccination in Taiwan. In recent years, the literature also provides evidence to prove the relationship between hepatitis C and chronic kidney disease, and it is also related to the concentration of albumin in the urine, so it is speculated which genotypes will be more likely to cause albumin loss in the body.Even the long-term kidney is insufficiency.
Method: This study used the 2007-2016 National Health and Nutrition Examination Survey (NHANES) public database to look for different Hepatitis C Genotypes (HCV) and Urine Concentration of Albumin data, to observe which HCV Genotypes would affect Urine albumin levels.
Results: Sample 40,856 HCV-RNA negative 237, positive 336, adjusted for gender, race, education, smoking, diabetes, hepatitis B, alcohol abuse, BMI in urine creatinine ratio in type C, hepatitis C, type II Genes are more likely to cause high concentrations (P < 0.001), but are less likely to be observed in albuminuria and renal spheroid filtration rates.
Conclusion: The second type of genotype that is most likely to cause loss was observed in the Albumin creatinine ratio. However, the Urine Concentration of Albumin and the estimated Glomerular filtration rate were not ideal. It may be that the number of samples is not enough, or some genotypes are rare. Insufficient force, it may be necessary to increase the number of samples to make a normal distribution. Hepatitis C is still a very important public health issue, must be made to find some connections, and hope that patients with hepatitis C get more treatment.
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