| Summary: | 碩士 === 國立嘉義大學 === 生化科技學系研究所 === 107 === Ginger is a Chinese herbal medicine that has hurricane, anemia, anti-inflammatory and anti-carcinogenic effects. Gingerol is a source of spicy taste in ginger.
Shogaol is the product of dehydration of gingerol. Shogoal has cholesterol-lowering effect, blood circulation promotion and immunity enhancement. In this experiment, non-extracted ginger solution (NS) was used as the control group, and no extraction heating for one hour (N1), extraction heating for one hour (S1), extraction heating for two hours (S2), and extraction heating for four hours (S4) as experiments group. DPPH clearance rate is 93 % (NS is 78 %). The total phenol content waS16 mg/g better thaN10 mg/g of NS.
In the MTT assay, different concentrations of S1 were added to the TSGH-9201 cells, and it was found that only 55 % of the cell viability remained under the effect of 5 % S1.
S1 and 5-FU alone or in combination could markedly suppress the proliferation of TSGH cells in a significant dose-dependent manner, and seemingly result from augmentation of p38 signaling. In animal experiments, the liver tissue particles of the experimental group were smaller than the control group, and the color was also closer to that of the normal mice. In the blood component test, the concentration of GOT, GPT, Triglyceride, and total cholesterol was lower in the experimental group that treated with ginger extract.
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