Process Parameter Study of Dip-drawing Technology for Making Microneedle Array

• Main Authors: Yang,Chieh-Cheng, 楊傑丞
• Other Authors: Wang, Kerwin
• Format: Others
• Language: zh-TW
• Published: 2019
• Online Access: http://ndltd.ncl.edu.tw/handle/69ktww

碩士 === 國立彰化師範大學 === 機電工程學系 === 107 === This paper presents a parameter study of the dip-drawing process of making high aspect-ratio polymeric microneedles. The process involves dip-pad spin coating, dip-drawing, UV-curing, necking, and breaking. To gain more insight into the process, we study three major process parameters including curing time, drawing speed, dip-mold’s tip diameter, they are critical parameters of the microneedle fabrication process. We also make different microneedles by setting a series of process parameters through dip-drawing platform. To prepare the experiment, we design an automatic dipping and drawing platform. The platform consists of a dip-mold holder, a dip-pad holder, a UV LED array, two stepping-motors, two threaded shaft systems, and a single board computer. The dip-mold is constructed of an acupuncture needle array. The dip-pad is prepared by spin-coating SU-8 (SU-2025). The single board computer acts as a human interface platform for a user to set up the dip-drawing process parameters including dip-drawing speed and curing time. User can operate this automatic platform to make various microneedles. The experiment results show that the dip-drawing process would yield sharpened high-aspect-ratio microneedles. At different drawing speeds, the radius of the microneedle tips gradually decreased with the increasing of the drawing speed. Under different UV curing time, the needle diameter decreased with the decreasing of curing time.