Synthetic Studies toward Landomycin E

• Main Authors: Yang, Yi-Ru, 楊易儒
• Other Authors: Mong, Kwok-Kong
• Format: Others
• Language: en_US
• Published: 2019
• Online Access: http://ndltd.ncl.edu.tw/handle/2hqgk8

碩士 === 國立交通大學 === 應用化學系碩博士班 === 107 === Landomycins are a family of natural products that belong to angucycline antibiotics. Landomycin E has been proved to have anti-proliferation activity toward several multi-drug resistant cancer cell lines including lung cancer cell line NCI-H460. Due to the potential anti-proliferation activity, the synthesis of landomycins has been always appealing many synthetic scientists. Landomycin E has a tetracyclic benz[a]anthraquinone (also known as landomycinone), and a deoxytrisaccharide chain. The deoxytrisaccharide chain joins to the 8-hydroxyl group of the landomycinone core structure via a β-glycosidic bond. In this study, we apply our established strategy of landomycinone to continue the synthetic study toward landomycin E. In my study, we try to address the issues that facing the precedents in the synthesis of landomycins.