| Summary: | 碩士 === 國立中興大學 === 獸醫學系暨研究所 === 107 === Metronomic chemotherapy (MC) is defined as the continuous oral administration of chemotherapeutic drugs at doses that are significantly lower than conventional maximally tolerated dose with no extended drug-free intervals. The mechanisms of MC included the effect on neovascularization, stimulating anticancer immune response and the induction of tumor dormancy. The aim of this study was to evaluate the clinical outcome of dogs with various malignant tumor treated with MC of cyclophosphamide (CTX) and/or piroxicam. This study was a retrospective study. One hundred and eighty-six dogs with malignant tumors and received CTX and/or piroxicam as MC were enrolled. The univariate analysis revealed that OST was significantly longer in the dogs treated with MC (CTX and/or piroxicam) greater than 28 days (P ＜ 0.001) and had undergone surgery (P ＜ 0.001) compared to dogs treated with MC (CTX and/or piroxicam) less than 28 days and without surgery. Furthermore, treated with MC (CTX and/or piroxicam) greater than 28 days and had undergone surgery were positively associated with significantly longer OST in dogs with distant metastasis. By multivariate analysis, treated with MC (CTX and/or piroxicam) greater than 28 days and had undergone surgery were the positive factors of longer OST. The overall response rate (including complete response or partial response) of MC (CTX and/or piroxicam) was 1.7%, while stable disease was noted in 58 dogs (33.3%). Two out of 186 dogs had grade 1 gastrointestinal toxicity. No grade 3 or 4 adverse effects were observed in dogs. Sterile hemorrhagic cystitis (SHC) occurred in 6 out of 186 dogs (3.2%). Median time to development SHC was 190 days. In conclusion, this study demonstrated that MC (CTX and/or piroxicam) treatment duration greater than 28 days and had undergone surgery had better outcomes in dogs with malignant tumors. Moreover, MC (CTX and/or piroxicam) was well-tolerated in dogs, but development of SHC should be concerned with dogs receiving MC (CTX and/or piroxicam).
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