| Summary: | 碩士 === 弘光科技大學 === 營養醫學研究所 === 107 === Migraine is the most common headache disorder in headache clinic. In Taiwan, the prevalence of migraine is approximately 9.1% and 1.7% in chronic migraine. Migraine could be triggered by many factors including stress, fasting, insufficient sleep or insomnia, emotional or weather changes, strenuous exercise, life style, odors, and some food. However, in the past, limited studies were conducted to evaluate whether these migraine trigger factors and the serum heavy metals play an important role in migraine frequency, intensity and headache symptoms. Thus, the aim of this study is to evaluate whether migraine trigger factors and serum heavy metals are related to migraine frequency, intensity, and headache symptoms.
This cross-sectional study was conducted in the neurology outpatient of one teaching regional hospital in central Taiwan between September 2017 to April 2018. In this study, 41 patients were recruited and among them 29 patients were diagnosed as episodic migraine and 12 patients were diagnosed as chronic migraine based on International classification of Headache disorder Third edition. All the patients were asked to complete a face- to-face interview by a qualified headache specialist using a detailed questionnaire for headache. Blood test was also performed to detect serum heavy metals level. Our results demonstrated that “insufficient sleep or insomnia” accounts for the most commonly trigger factor. However, there were no differences among migraine frequency, intensity and migraine symptoms with migraine trigger factors. Moreover, the serum nickel level was positively correlated with “explosive headache” and serum copper, lead, arsenic and zinc level were positively correlated with "insufficient sleep or insomnia". In addition, the serum nickel level was positively correlated with "cleaning solution or ammonia". The frequency of migraine attacks was negatively correlated with serum arsenic level. Because of limited numbers of patient, in this study these findings remain to be validated in future larger and multi-center studies.
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