| Summary: | 碩士 === 國立雲林科技大學 === 化學工程與材料工程系 === 106 === This study investigated the pectinous polysaccharides extracted from Ficus awkeotsang Makino was prepared as a candidate material for colon-specific capsule. First, the casted films will be characterized by Fourier transform infrared (FT-IR) spectroscopy, color test, thickness test, water content test, and some mechanical properties. The seeds of F. awkeotsang Makino are a rich source of polysaccharides which are majorly composed of low-methyl pectin with other minor components including hemicellulose and protein. In this project, the pectinous polysaccharide extracted from the seed of F. awkeotsang Makino was evaluated for its applicability in hard capsule production. Result showed Ficus. polysaccharide film had thickness values with 99.3 ㎛, which is quite similar to the market. The tensile strength test results were approximately 20 MPa, which was not significantly different from gelatin. In the experiment of prepared capsules, it was found that Ficus. polysaccharide could not be attached to the appliance, and the excessive concentration of Ficus. polysaccharide would make the solution jellied, resulted in using the Ficus. polysaccharide as sole ingredient for hard capsule preparation is not successful. So, we added low concentration of xanthan gum as a thickener and stabilizer and added resistant starch as an excipient to optimize the formulation of hard capsules. In vitro experiment showed that the F. awkeotsang Makino mixture could not be degraded in the simulated gastric and intestinal fluids but degraded in simulated colonic fluids (the release rate from the 6 h to the 7 h increased from 15% to 90%). Therefore, Ficus. polysaccharide may be a potential material for colon-targeted capsule.
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