Specific Tumor Microenvironment Responsive Polymeric Micelles for Cancer Chemotherapy

• Main Authors: Hui-Ching Chang, 張惠晴
• Other Authors: Chun-Liang Lo
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/78zh9n

碩士 === 國立陽明大學 === 生物醫學工程學系 === 106 === In the progress of medical science, most cancers achieve favorable therapeutic outcome nowadays. However, pancreatic cancer remains a fatal disease, there is an urgent need to make a breakthrough in pancreatic cancer treatment. The development of drug delivery system had attracted much attention in chemotherapy. In this study, we designed a specific tumor microenvironment responsive polymer mPEG-Poly (Glutamic acid-alt-Methionine)-NH2 (mPEG-PGM) to deliver platinum drug for pancreatic cancer therapy. In the results of dynamic light scattering and Transmission electron microscope, the particle size and morphology was 65 nm and spherical respectively. This polymer micelle has the ability to response to reactive oxygen species (ROS) and release Pt drug to induce the cell apoptosis in the high concentration of H2O2 tumor microenvironment. In addition, the anti-cancer drug DACH Pt contains platinum, which enables an synergy effect between chemotherapy and radiation therapy. The results of DLS showed that the polymer micelles were responsive to high-oxidation environment. Moreover, the vitro test, demonstrated that the PGM-30 micelles combining with radiotherapy enhanced the toxicity in PANC-1 cells In addition, the PGM-30 micelles had the ability of selective cytotoxicity in normal cell to reduce the side effect. Those results proved that mPEG-PGM polymer micelles has the potential to treat pancreatic cancer.