| Summary: | 碩士 === 國立臺北科技大學 === 製造科技研究所 === 106 === Most glucose meters on the market now are equipped with software programmed for temperature compensation. One of the compensation mechanisms is to adjust the blood glucose level by ±1% when the ambient temperature decreases or increases by roughly 2℃. Despite the rough estimation, the result can be affected by numerous external factors. The purpose of the study is to investigate the impact of ambient temperature on the overall glucose monitoring system, especially glucose meters, glucose test strips, blood temperature and source of the blood.
The study utilized a custom-made ambient temperature glove compartment for simulation of glucose measurement under ambient temperatures. For the glucose meter system, we used commercial Accu-Check Performa (Roche) and glucose test strips. The entire experiment was divided into the following parameters: (1) glucose test strips, Accu-Check Performa, venous blood at warm temperature (2) glucose test strips, venous blood at warm temperature and Accu-Check Performa at 25℃ room temperature (3) Accu-Check Performa, venous blood at warm temperature, glucose test strips at 25℃ room temperature (4) glucose test strips, Accu-Check Performa, venous blood at 25℃ room temperature. Pre-warmed devices were placed in the glove compartment until reaching the desired temperature (1hr) before taking measurements. After the measurements have been taken, warm blood samples were removed from the compartment and glucose levels were measured by the third-party devices YSI 2300 and YSI 2700 for confirmation. Readings of YSI were compared with those of Accu-Check (Roche).
The study result showed when using fresh venous blood for the glucose measurement, the group with warm devices had the largest percent deviation from the YSI readings. The temperature impact was greater on glucose test strips than glucose meters. At higher temperatures, the maximum percent deviation from YSI was up to -20.1%. When using refrigerated venous blood for glucose measurement, the group with warm devices also had the largest percent deviation from the YSI readings with greater impact on the glucose test strips than glucose meter. At a higher temperature, the maximum YSI percent deviation was up to -33.3%. All deviations of refrigerated venous blood were greater than those of fresh blood.
The study further investigated the relative impact of glucose monitoring system on ambient temperature and the relative correlation between glucose meter vs. ambient temperature and glucose test strips vs. ambient temperature. As readings from fresh venous blood were more stable than those from refrigerated venous blood, it is advised to use fresh venous blood with live cells for experiments of the glucose monitoring system. The experiment should also be performed at room temperature to avoid experimental deviations due to incomplete temperature compensation system.
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