Systematic Review of Serenoa Repens Extract onCeasing Androgenic Alopecia Progression

• Main Authors: Yang, Ya-Ling, 楊雅齡
• Other Authors: Liao, Hung-En
• Format: Others
• Language: en_US
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/psh8qg

碩士 === 亞洲大學 === 健康產業管理學系健康管理組碩士在職專班 === 106 === Background Hair loss problem affect both men and women. Androgenic alopecia (AGA) is the most common type of male pattern hair loss. The hair loss pattern usually begins with bitemporal recession, followed by the frontal and vertex areas. But the occipital area is not affected by androgen activity due to lack of androgen receptor. The enzyme 5 alpha-reductase plays on important role in AGA. The conversion of testosterone to dihydrotestosterone (DHT) is catalyzed by the enzyme 5 alpha-reductase. Several plants were noted as having 5 alpha-reductase inhibition potential due to its phytochemicals. Serenoa repens is one of these plants which have been common used in Europe for benign prostate hyperplasia. Systemic review was used to investigate the improving human hair growth effect of Serena Repens. Objectives This systematic review aimed to assess the effects and harms of Serenoa repens in the treatment of men with androgenic alopecia. Search method We use PubMed as our primary research database. The Cochrane and WOS were also searched. Selection Criteria The following keywords were used for searching: 5 alpha-reductase, serenoa repens and human hair growth. Result There are four literatures meet the criteria of our study. It seems effective to treat AGA through topical use and oral treatment. In the topical use study, the terminal hair counts continue increasing at end of trial. Although different formulation of serenoa repens extract, the stabilization of hair loss condition and improving the hair bulb phase proportion are the relative noteworthy effect. In the serenoa repens and finasteride comparison study, serenoa repens lead an improvement only in vertex. Finasteride improved hair growth in all area. Conclusion The products of serenoa repens extract, in topical use or oral intake form, are safe and no sexual dysfunction side effect which was one of concerned reason by patients.