| Summary: | 碩士 === 南臺科技大學 === 生物科技系 === 106 === Heart failure (HF) is a very complex disease. According to statistics, heart disease is the second leading cause of death in Taiwan, and the longest period of hospitalization for heart disease is heart failure. Even advanced Countries in Medicine, around 50% of people diagnosed with heart failure will die within 5 years, much higher than the cancer incidence of colorectal cancer mortality (35%). Heart failure may be caused by acute injury, complications such as myocardial infarction, renal insufficiency, high blood pressure and aortic stenosis. And these diseases will produce heart volume or pressure overload then myocardial dysfunction and increased risk of ventricular remodeling and myocardial cell hypertrophy and apoptosis caused by the deterioration leading to heart failure conditions. We assessed whether Sea buckthorn fruit oil unsaturated fatty acids (UFAs) have the protective effect on the cardiac myocyte hypertrophy and apoptosis.
The renin-angiotensin system has a regulatory role in the physiological and pathological responses of the cardiovascular system. The main effector hormone, angiotensin II (ANG II) has direct effects on cardiomyocytes, including cardiomyocyte growth, accumulation of extracellular matrix and hypertrophy, and over-expression of β-MHC, α-MHC, ANP and BNP. Studies have shown that unsaturated fatty acids can help protect the kidneys, protecting the heart through mechanisms such as lowering blood pressure and triglycerides, maintain hemodialysis, reduce inflammation-related muscle loss, and even reduce mortality.
Seabuckthorn (sea-buckthorn), contains several substances, such as vitamins, amino acids, trace elements, flavonoids, organic acids, phenols and fatty acids, especially fruit oil rich in unsaturated fatty acids.This research topic is unsaturated fatty acids (MUFAs) in sea buckthorn fruit oil. In the cellular injury model, we evaluated whether MUFAs can inhibit the hypertrophy induced by ANG II or inhibit cell death induced by hypoxia-induced apoptosis case, and preliminary assessment by MTT whether seabuckthorn extract samples could mitigate cellular damage caused by two types of induction patterns.
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