Application of Carbon Nanohorns Loaded Carbon Dot-coated Iron Oxide Nanoparticles to Multiple Therapies

• Main Author: Andree Soendoro
• Other Authors: Toyoko Imae
• Format: Others
• Language: en_US
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/3x32ge

碩士 === 國立臺灣科技大學 === 化學工程系 === 106 === Carbon nanohorns as the drug carrier were modified by attaching the carbon dots coated iron oxide nanoparticles (CNH/Fe3O4@C) in order to perform multiple therapies and to improve their performance. CNH/Fe3O4@C has been successfully synthesized as previously reported for combination therapy of hyperthermia and chemotherapy. Iron oxide nanoparticles that showed a good magnet response are responsible to hyperthermia. Meanwhile, the carbon dots due to its ability to produce singlet oxygen as previous report are responsible to photodynamic therapy (PDT). Towards chemotherapy study, CNH/Fe3O4@C enhanced the doxorubicin (DOX) loading, DOX release and also gemcitabine loading, gemcitabine release. The temperature dependency of DOX release and gemcitabine release was also measured and resulted higher drug release in higher temperature. Towards the PDT study, the singlet oxygen generated by CNH/Fe3O4@C was examined. Furthermore, the combination of drug release and light irradiation has been performed and showed a good outcome in drug release.