Relationship between air pollution and metal concentration in cord blood

• Main Authors: Shih-Ting Lei, 雷士霆
• Other Authors: Yue-Liang Guo
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/pzg28j

碩士 === 國立臺灣大學 === 職業醫學與工業衛生研究所 === 106 === Background Air pollutants may enter the body through inhalation and affect human health. Metals belong to a component of air pollutants, and often exist with small particles, The goal of this investigation is to understand the relationship between air pollution and cord blood vanadium, strontium and arsenic concentrations. Materials and Methods A birth cohort, including 893 pairs of mothers and newborns were recruited between May 2004 to July 2005. Structured questionnaire was completed, which contained basic information on maternal and newborn data, information of home environment, and information on enviromental exposure. Cord blood samples were analyzed by inductively coupled plasma mass spectrometry (ICP-MS), for vanadium, strontium and arsenic. Air pollution data was collected from the EPA air monitoring stations and individual exposure was extrapolated using geographic information system (Arc GIS) Kriging method. Multiple linear regression analysis was performed to determine the relationship between metal concentrations in cord blood and air pollution by SAS 9.4 software. Results After adjusting the mother''s age, education level, family income, maternal smoking, passive smoking, alcohol drinking, gestation weeks, birth season and baby gender, cord blood vanadium was significantly positively associated with PM10. Comparing those living in higher and lower PM10 regions, there was 0.39 μg/L difference in cord blood vanadium. Cord blood arsenic concentration was significantly positively associated with SO2. Comparing those living in higher and lower SO2 regions, there was 0.81 μg/L difference in cord blood arsenic. Conclusion The study found that cord blood vanadium concentrations is associated with maternal exposure to ambient PM10, and cord blood arsenic concentrations is associated with maternal exposure to ambient SO2. Since these two metals are known to be emitted from petrochemical industries, the contribution of the latter to cord blood vanadium and arsenic cannot be totally ruled out.