The effect of pure compound AG in a transgenic mice model of Alzheimer’s disease

• Main Authors: Song, Yan-Qing, 宋彥慶
• Other Authors: Lin, Yen-shou
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/sdtbd5

碩士 === 國立臺灣師範大學 === 生命科學系 === 106 === There were approximately 48 million people developing Alzheimer’s disease (AD), one of the most common neurodegenerative diseases. Nevertheless, there is no cure for this disease so that the related drug development becomes warranted. We have previously found 6 out of 12 Chinese herbal medicines (CHMs) have the potential to ameliorate abnormally neuronal depolarization by using our drug screening platform. One of the pure compounds, temporarily named AG, has also been investigated its cellular mechanism on the primary neurons. Therefore, the efficacy of AG on AD mice model, J20, is further investigated. Mice were divided into four groups, wild type or J20 were injected with or without AG. AG were injected into mice subcutaneously for a month. The H&E staining of liver and kidney tissues showed no significant change compared to the ones injected by vehicle. AG doesn’t recover the hyperactivity and temporary memory in J20 mice assayed by using open field test and Y-maze analysis. AG can’t alleviate the memory loss in the mouse model analyzed by utilizing Morris water maze. However, AG can enhance the short-term and long-term memory on wild-type mice. Taken together, current format/timing of giving AG to mice shows inconclusive effect on memory deterioration of J20 mice. It has the benefit on enhancing memory of normal mice. Hence, it could still has the potential to develop into a dietary supplement on enhancing memory.