Cu-Catalyzed Aerobic Oxidation in the Synthesis of Quinolinium Salts from Secondary Amines, Alkynes, Formaldehyde and Acid

碩士 === 國立清華大學 === 化學系所 === 106 === Substituted heterocyclic nitrogen salts are versatile building blocks for a number of natural products and bioactive motifs. Herein, we report a novel and convenient process to synthesize quinolinium salt derivatives by Cu-catalyzed aerobic oxidative coupling of se...

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Main Authors:	Cheng, Lin-Chieh, 鄭琳潔
Other Authors:	Cheng, Chien-Hong
Format:	Others
Language:	zh-TW
Published:	2018
Online Access:	http://ndltd.ncl.edu.tw/handle/dg5crz

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spelling	ndltd-TW-106NTHU50650472019-06-27T05:28:45Z http://ndltd.ncl.edu.tw/handle/dg5crz Cu-Catalyzed Aerobic Oxidation in the Synthesis of Quinolinium Salts from Secondary Amines, Alkynes, Formaldehyde and Acid 銅金屬催化胺、炔、醛氧化環化反應以合成喹啉鹽類 Cheng, Lin-Chieh 鄭琳潔碩士國立清華大學化學系所 106 Substituted heterocyclic nitrogen salts are versatile building blocks for a number of natural products and bioactive motifs. Herein, we report a novel and convenient process to synthesize quinolinium salt derivatives by Cu-catalyzed aerobic oxidative coupling of secondary amine, alkyne and formaldehyde. The reaction proceeds via acid induced N,N-disubstituted iminium ion formation followed by nucleophilic addition of alkyne, annulation, and copper-promoted oxidation. This method features an economical catalyst, one pot process, ambient reaction temperature and short reaction time. Cheng, Chien-Hong 鄭建鴻 2018 學位論文 ; thesis 112 zh-TW
collection	NDLTD
language	zh-TW
format	Others
sources	NDLTD
description	碩士 === 國立清華大學 === 化學系所 === 106 === Substituted heterocyclic nitrogen salts are versatile building blocks for a number of natural products and bioactive motifs. Herein, we report a novel and convenient process to synthesize quinolinium salt derivatives by Cu-catalyzed aerobic oxidative coupling of secondary amine, alkyne and formaldehyde. The reaction proceeds via acid induced N,N-disubstituted iminium ion formation followed by nucleophilic addition of alkyne, annulation, and copper-promoted oxidation. This method features an economical catalyst, one pot process, ambient reaction temperature and short reaction time.
author2	Cheng, Chien-Hong
author_facet	Cheng, Chien-Hong Cheng, Lin-Chieh 鄭琳潔
author	Cheng, Lin-Chieh 鄭琳潔
spellingShingle	Cheng, Lin-Chieh 鄭琳潔 Cu-Catalyzed Aerobic Oxidation in the Synthesis of Quinolinium Salts from Secondary Amines, Alkynes, Formaldehyde and Acid
author_sort	Cheng, Lin-Chieh
title	Cu-Catalyzed Aerobic Oxidation in the Synthesis of Quinolinium Salts from Secondary Amines, Alkynes, Formaldehyde and Acid
title_short	Cu-Catalyzed Aerobic Oxidation in the Synthesis of Quinolinium Salts from Secondary Amines, Alkynes, Formaldehyde and Acid
title_full	Cu-Catalyzed Aerobic Oxidation in the Synthesis of Quinolinium Salts from Secondary Amines, Alkynes, Formaldehyde and Acid
title_fullStr	Cu-Catalyzed Aerobic Oxidation in the Synthesis of Quinolinium Salts from Secondary Amines, Alkynes, Formaldehyde and Acid
title_full_unstemmed	Cu-Catalyzed Aerobic Oxidation in the Synthesis of Quinolinium Salts from Secondary Amines, Alkynes, Formaldehyde and Acid
title_sort	cu-catalyzed aerobic oxidation in the synthesis of quinolinium salts from secondary amines, alkynes, formaldehyde and acid
publishDate	2018
url	http://ndltd.ncl.edu.tw/handle/dg5crz
work_keys_str_mv	AT chenglinchieh cucatalyzedaerobicoxidationinthesynthesisofquinoliniumsaltsfromsecondaryaminesalkynesformaldehydeandacid AT zhènglínjié cucatalyzedaerobicoxidationinthesynthesisofquinoliniumsaltsfromsecondaryaminesalkynesformaldehydeandacid AT chenglinchieh tóngjīnshǔcuīhuàànguìquányǎnghuàhuánhuàfǎnyīngyǐhéchéngkuílínyánlèi AT zhènglínjié tóngjīnshǔcuīhuàànguìquányǎnghuàhuánhuàfǎnyīngyǐhéchéngkuílínyánlèi
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Cu-Catalyzed Aerobic Oxidation in the Synthesis of Quinolinium Salts from Secondary Amines, Alkynes, Formaldehyde and Acid

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