| Summary: | 碩士 === 國立中山大學 === 機械與機電工程學系研究所 === 106 === This research studied the development and characterisation of the bioceramic drug delivery cement composed of calcium sulfate dihydrate (CSD), calcium phosphate cement (CPC), simvastatin and collagenase for the vital pulp therapy. The CSD, CPC, simvastatin and collagenase were utilised as drug delivery system for achieving the goal of stimulating the differentiation of dental pulp stem cells. The CSD and CPC powders were blended with 3:7, 5:5 and 7:3 mixture ratios for forming biphasic ceramic cement named CPC3CSD7, CPC5CSD5 and CPC7CSD3. The CPC7CSD3 cement performed feasible physical properties, favourable biocompatibility, and well alkaline phosphatase (ALP) activity. The mean pore size was approximate 250 nm which can provide well pore channels for embedded simvastatin and collagens releases. The release profiles of the embedded drugs from the biphasic cement were studied and the 31.2% of collagenase and 34.1% of simvastatin were naturally diffused out from the cement within 4 days. The cell viability test was presented approximate 50% increase in cell proliferation after 3 days. The ALP activity proved the differentiation to osteoblasts and the value was 2.8. Therefore, we believe that this development has the high potential to be applied for the pulp therapy in the clinical dentistry.
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